Skip directly to search Skip directly to A to Z list Skip directly to navigation Skip directly to page options Skip directly to site content


Hot Topics of the Day|PHGKB
Search PHGKB:

Archive

Hot Topics of the Day are picked by experts to capture the latest information and publications on public health genomics and precision health for various diseases and health topics. Sources include published scientific literature, reviews, blogs and popular press articles.

Sign up MyPHGKB to receive the daily hot topic email alert.

Search Archive:
Archived Hot Topics of the Day By Date
31 hot topic(s) found with the query "Post traumatic stress disorder"

Predictive evidence of the relevance of epigenetics to PTSD.
Leon Mutesa et al. Nat Rev Genet 2023 8 (Posted: Aug 09, 2023 4PM)

Post-traumatic stress disorder (PTSD) is a complex mental health condition that can occur after a life-threatening or otherwise traumatic event. Although its molecular causes are unclear, its development is thought to involve a range of biological, psychological and environmental factors. In 2009, Yehuda and Bierer posited that epigenetic modifications, such as DNA methylation, may occur in response to environmental influences such as trauma exposure, thus altering the functional expression of genes. These mechanisms may explain the intergenerational transmission of PTSD across affected families.

The performance of artificial intelligence-driven technologies in diagnosing mental disorders: an umbrella review
A Abd-Alrazak et al, NPJ Digital Medicine, July 7, 2022 (Posted: Jul 08, 2022 7AM)

We included 15 systematic reviews of 852 citations identified. The included reviews assessed the performance of AI models in diagnosing Alzheimer’s disease (n?=?7), mild cognitive impairment (n?=?6), schizophrenia (n?=?3), bipolar disease (n?=?2), autism spectrum disorder (n?=?1), obsessive-compulsive disorder (n?=?1), post-traumatic stress disorder (n?=?1), and psychotic disorders (n?=?1). The performance of the AI models in diagnosing these mental disorders ranged between 21% and 100%. AI technologies offer great promise in diagnosing mental health disorders. The reported performance metrics paint a vivid picture of a bright future for AI in this field.

https://www.nature.com/articles/s41591-020-0951-z
K Schultebrauks et al, Nature Medicine, July 6, 2020 (Posted: Jul 06, 2020 11AM)

We develop and validate an algorithm for prediction of post-traumatic stress course over 12 months using two independently collected prospective cohorts of trauma survivors from two level 1 emergency trauma centers, using routinely collectible data from electronic medical records, along with brief clinical assessments of the patient’s immediate stress reaction.

First Biomarker-Based Screening Tool for PTSD
J Abbasi, JAMA, September 25, 2019 (Posted: Sep 26, 2019 8AM)

A new biomarker panel that screens for posttraumatic stress disorder (PTSD) accurately differentiated combat-exposed US veterans with and without the condition in a recent study. If approved by regulators, the panel could be the first objective screening test for PTSD—or any psychiatric condition.

Multi-omic biomarker identification and validation for diagnosing warzone-related post-traumatic stress disorder.
Dean Kelsey R et al. Molecular psychiatry 2019 Sep (Posted: Sep 12, 2019 7AM)

Genomic Characterization of Posttraumatic Stress Disorder in a Large US Military Veteran Sample
MB Stein et al, BioRXIV, September 10, 2019 (Posted: Sep 11, 2019 9AM)

Using genetic data from more than 250,000 participants in the Million Veteran Program, genomewide association analyses were conducted using electronic health record-based PTSD diagnosis phenotype and PTSD quantitative symptom phenotypes. The study identified several genome-wide significant loci.

Genome-wide association study of post-traumatic stress disorder reexperiencing symptoms in >165,000 US veterans
J Gelernter et al, Nat NeuroSci, July 29, 2019 (Posted: Jul 30, 2019 8AM)

A genome-wide association study included 146,660 European Americans and 19,983 African Americans in the US Million Veteran Program, sought to identify genetic risk factors relevant to intrusive reexperiencing of trauma, which is the most characteristic symptom cluster of PTSD. In European Americans, eight distinct significant regions were identified.

Polygenic risk associated with post-traumatic stress disorder onset and severity.
Misganaw Burook et al. Translational psychiatry 2019 Jun (1) 165 (Posted: Jun 19, 2019 8AM)

Largest genome-wide association study for PTSD identifies genetic risk loci in European and African ancestries and implicates novel biological pathways
BioRXIV preprints, November 1, 2018 (Posted: Nov 04, 2018 0PM)

Genetic approaches for the study of PTSD: Advances and challenges.
Banerjee Sunayana B et al. Neuroscience letters 2017 May 139-146 (Posted: Feb 08, 2018 8AM)

Apolipoprotein E variants and genetic susceptibility to combat-related post-traumatic stress disorder: a meta-analysis.
Roby Yang et al. Psychiatric genetics 2017 Aug (4) 121-130 (Posted: Feb 08, 2018 8AM)

Alpha-Adrenergic Receptors in PTSD - Failure or Time for Precision Medicine?
Ressler Kerry J et al. The New England journal of medicine 2018 Feb (6) 575-576 (Posted: Feb 08, 2018 8AM)

Pharmacogenetics and Pharmacotherapy of Military Personnel Suffering from Post-traumatic Stress Disorder.
Naß Janine et al. Current neuropharmacology 2017 (6) 831-860 (Posted: Sep 07, 2017 3PM)

Pretreatment biomarkers predicting PTSD psychotherapy outcomes: A systematic review.
Colvonen Peter J et al. Neuroscience and biobehavioral reviews 2017 Apr 140-156 (Posted: Sep 07, 2017 3PM)

The genetics and epigenetics of PTSD: overview, recent advances, and future directions.
Sheerin Christina M et al. Current opinion in psychology 2017 Apr 5-11 (Posted: Sep 07, 2017 3PM)

What is Post-Traumatic Stress Disorder
National Institute for Mental Health Brand (Posted: Sep 07, 2017 3PM)

Alterations in blood-based miRNA in veterans affected with combat-related PTSD
Science Mag, Sep 7, 2017 (Posted: Sep 07, 2017 2PM)

Epigenetic and genetic variation at SKA2 predict suicidal behavior and post-traumatic stress disorder.
Kaminsky Z et al. Transl Psychiatry 2015 e627 (Posted: Sep 09, 2015 11AM)

Variation in SLC1A1 is related to combat-related posttraumatic stress disorder.
Zhang Jingmei et al. J Anxiety Disord 2014 Dec (8) 902-7 (Posted: May 17, 2015 10AM)

Association of COMT and TPH-2 genes with DSM-5 based PTSD symptoms.
Goenjian Armen K et al. J Affect Disord 2014 Oct 22. 472-478 (Posted: May 17, 2015 10AM)

Genomic predictors of combat stress vulnerability and resilience in U.S. Marines: A genome-wide association study across multiple ancestries implicates PRTFDC1 as a potential PTSD gene.
Nievergelt Caroline M et al. Psychoneuroendocrinology 2015 Jan 459-71 (Posted: May 17, 2015 10AM)

The Number of Cysteine Residues per Mole in Apolipoprotein E Is Associated With the Severity of PTSD Re-Experiencing Symptoms.
Peterson Carly K et al. J Neuropsychiatry Clin Neurosci 2015 (2) 157-61 (Posted: May 17, 2015 10AM)

Gene networks specific for innate immunity define post-traumatic stress disorder.
Breen M S et al. Mol. Psychiatry 2015 Mar 10. (Posted: May 17, 2015 10AM)

Mitochondrial genetic variants identified to be associated with posttraumatic stress disorder.
Flaquer A et al. Transl Psychiatry 2015 e524 (Posted: May 17, 2015 10AM)

Searching for non-genetic molecular and imaging PTSD risk and resilience markers: Systematic review of literature and design of the German Armed Forces PTSD biomarker study.
Schmidt Ulrike et al. Psychoneuroendocrinology 2015 Jan 444-58 (Posted: May 17, 2015 10AM)

Progress towards understanding the genetics of posttraumatic stress disorder.
Voisey Joanne et al. J Anxiety Disord 2014 Dec (8) 873-83 (Posted: May 17, 2015 10AM)

Systems biology approach to understanding post-traumatic stress disorder.
Thakur Gunjan S et al. Mol Biosyst 2015 Apr (4) 980-93 (Posted: May 17, 2015 10AM)

Biological correlates of complex posttraumatic stress disorder-state of research and future directions.
Marinova Zoya et al. Eur J Psychotraumatol 2015 25913 (Posted: May 17, 2015 10AM)

The Psychiatric Genomics Consortium Posttraumatic Stress Disorder Workgroup: Posttraumatic stress disorder enters the age of large-scale genomic collaboration.
Logue Mark W et al. Neuropsychopharmacology 2015 Apr 23. (Posted: May 17, 2015 10AM)

Epigenetics of Posttraumatic Stress Disorder: Current Evidence, Challenges, and Future Directions.
Zannas Anthony S et al. Biol. Psychiatry 2015 Apr 7. (Posted: May 17, 2015 10AM)

What is Post-traumatic Stress Disorder (PTSD)?
Health Topics from the National Institute for Mental Health Brand (Posted: May 17, 2015 10AM)


Disclaimer: Articles listed in Hot Topics of the Day are selected by Public Health Genomics Branch to provide current awareness of the scientific literature and news. Inclusion in the update does not necessarily represent the views of the Centers for Disease Control and Prevention nor does it imply endorsement of the article's methods or findings. CDC and DHHS assume no responsibility for the factual accuracy of the items presented. The selection, omission, or content of items does not imply any endorsement or other position taken by CDC or DHHS. Opinion, findings and conclusions expressed by the original authors of items included in the Clips, or persons quoted therein, are strictly their own and are in no way meant to represent the opinion or views of CDC or DHHS. References to publications, news sources, and non-CDC Websites are provided solely for informational purposes and do not imply endorsement by CDC or DHHS.
TOP